Pre-specified vs. post-hoc subgroup analyses: are we wiser before or after a trial has been performed?
نویسنده
چکیده
Pivotal trials on antithrombotic regimens in coronary artery disease have been performed with huge patient cohorts; in CURE, 12 562 patients were randomized, TRITON-TIMI 38 included 13 608 patients, and PLATO 18 624 patients. Such databases provide an extraordinary opportunity to study a treatment effect in several subgroups of patients which—although subsets—still consist of thousands of patients. Such a subanalysis of the non-ST-segment elevation myocardial infarction ( NSTEMI) population in PLATO (a subgroup by itself) has now been published, differentiating patients with or without revascularization.
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عنوان ژورنال:
- European heart journal
دوره 35 31 شماره
صفحات -
تاریخ انتشار 2014